Everolimus 10 mg (Evertor 10 mg)

Description

What is Everolimus 10 mg?

Everolimus, sold under brand names like Afinitor, Afinitor Disperz, and Zortress, is a medication that belongs to a group of drugs known as kinase inhibitors. It’s used for two main purposes: preventing organ transplant rejection and treating certain noncancerous and cancerous tumors.

The specific brand and dosage of everolimus vary depending on the condition being treated:

• Afinitor (available in 2.5 mg, 5 mg, 7.5 mg, and 10 mg tablets) and Afinitor Disperz (available in 2 mg, 3 mg, and 5 mg tablets for oral suspension) are typically used to treat certain types of tumors.
• Zortress (available in 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg tablets) is used to prevent the rejection of transplanted organs, like a liver or kidney.

Everolimus works by targeting a specific protein in the body called mTOR (mammalian target of rapamycin). This protein plays a key role in controlling how cells grow, multiply, form new blood vessels, and use nutrients.

When treating tumors, everolimus reduces the blood supply to the tumor, which helps slow its growth. It does this by binding to a protein called FKBP-12, forming a complex that blocks mTOR’s activity.

In the case of organ transplants, everolimus acts as an immunosuppressant. This means it helps prevent your immune system from attacking the new organ. Normally, certain white blood cells (lymphocytes) would target anything they see as foreign, including a transplanted organ. Everolimus prevents these cells from becoming active and multiplying, thereby reducing the risk of organ rejection.

What is everolimus used for?

Afinitor, a brand of everolimus, is prescribed to treat several specific types of cancer and tumors:

1. Breast Cancer: It’s used for postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer. It is given along with exemestane when other treatments haven’t worked.
2. Pancreatic Cancer: Pancreatic is prescribed for adults with a type of pancreatic cancer known as pancreatic neuroendocrine tumor (PNET) that has progressed and can’t be treated with surgery.
3. Neuroendocrine Tumors (NET): It helps adults with neuroendocrine tumors of the stomach, intestines, or lungs that have advanced and can’t be removed surgically. However, it’s not for those with carcinoid tumors that produce hormones.
4. Kidney Cancer (RCC): RCC is for adults with advanced kidney cancer when other treatments have failed.
5. Tuberous Sclerosis Complex (TSC)-related Tumors:
   • Kidney Tumors: It treats adults with a kidney tumor called angiomyolipoma, which doesn’t require immediate surgery.
   • Brain Tumors (SEGA): It’s used for adults and children (1 year and older) with subependymal giant cell astrocytoma (SEGA) that can’t be fully removed by surgery.

The Afinitor Disperz brand is specifically for:

• Tuberous Sclerosis Complex (TSC):
  • Brain Tumors (SEGA): Treats adults and children (1 year and older) with SEGA when surgery isn’t an option.
  • Seizures (Epilepsy): Used as an additional treatment for adults and children (2 years and older) with certain types of seizures linked to TSC.

The Zortress brand of everolimus is used to prevent transplant rejection:

• Kidney Transplants: It is given with other medicines like cyclosporine and corticosteroids to prevent rejection in people who’ve had a kidney transplant.
• Liver Transplants: It’s also used with tacrolimus and corticosteroids for those who’ve had a liver transplant.

It’s important to note that the safety and effectiveness of everolimus have not been established in:

• Children for treating breast cancer, neuroendocrine tumors, kidney cancer, or TSC-related kidney tumors.
• Organ transplants other than kidney and liver.
• Children under 18 years of age for the Zortress brand.

Othe Doses of Everolimus:

Everolimus 5 mg

What should I do if I forget a dose?

If you miss a dose and remember within 6 hours, take it as soon as you can. If it is been more than 6 hours, just skip the missed dose and take your next one at the regular time. Don’t double up to make up for a missed dose.

What is the side effects of Everolimus 10 mg?

Everolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

More common

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody nose
• chest pain or tightness
• chills
• cough
• decreased weight
• diarrhea
• difficult or labored breathing
• difficulty with swallowing
• fever
• general feeling of discomfort or illness
• hoarseness
• lower back or side pain
• painful or difficult urination
• rapid weight gain
• sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• tingling of the hands or feet

Less common

• Black, tarry stools
• bladder pain
• bleeding gums
• bloody urine
• blurred vision
• body aches or pain
• burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
• coughing up blood
• difficult, burning, or painful urination
• ear congestion
• fast, pounding, or irregular heartbeat or pulse
• frequent urge to urinate
• headache
• increased fat deposits on the face, neck, and trunk
• increased thirst or urination
• irregular breathing
• loss of appetite
• loss of voice
• nausea
• nervousness
• nosebleeds
• pain, redness, or swelling in the arm or leg
• pale skin
• pinpoint red spots on the skin
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine
• sneezing
• sore throat
• slow heartbeat
• stomach ache
• stuffy or runny nose
• sweating
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting

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Rare

• Bloating
• change in mental status
• chest discomfort
• constipation
• dark or bloody urine
• difficulty speaking
• increased or decreased urination
• indigestion
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• pains in the stomach, side, or abdomen, possibly radiating to the back
• seizures
• sudden weakness in the arms or legs
• swelling of the face, fingers, feet, or lower legs
• yellow eyes or skin

Incidence not known

• Agitation
• confusion
• decreased awareness or responsiveness
• depression
• dizziness
• hostility
• irritability
• muscle twitching
• severe sleepiness
• unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Change in taste
• dry skin
• itching skin or rash
• lack or loss of strength
• loss of taste
• pain in the arms or legs
• trouble sleeping

Less common

• Back pain
• blistering, peeling, redness, or swelling of the palms, hands, or bottoms of the feet
• bumps on the skin
• burning, dry, or itching eyes
• difficulty in moving
• discoloration of the fingernails or toenails
• feeling of fullness
• flushing or redness of the skin
• jaw pain
• joint pain
• muscle cramps, spasms, or stiffness
• muscle or bone pain
• numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
• passing of gas
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.